Diagnosis of Chagas disease in patients with heart disease in an endemic area of Guatemala
DOI:
https://doi.org/10.54495/Rev.Cientifica.v23i1.111Keywords:
heart disease, Chagas disease, immunoassayAbstract
The purpose of this study was to determine the frequency of Chagas disease in patients with heart disease in endemic areas of Guatemala (Zacapa, Santa Rosa, Jalapa, Jutiapa), from November 2010 to July 2011, to determine the most common heart disease and compare the data with studies carried out in previous years. The sample was comprised of 156 patients who underwent an epidemiological survey and blood sample extraction to detect antibodies to T. cruzi by qualitative ELISA enzyme immunoassay and the results were confirmed with the solid phase ELISA. The data were statistically analyzed with one tail hypothesis test and test of proportions.
A decrease in the prevalence of Chagas’ disease in patients with cardiac disorders was observed from 21.6%, reported by the Japanese cooperation agency –JICA in 1995, to 14.7% reported in the present study (p = 0.0473) with limit of error for the estimation of 5.6%. The most common cardiac alterations found was the left ventricular hypertrophy (17.4%) and ischemic dilated cardiomyopathy (17.4%).
It is likely that this frequency decrease was generated due to the implementation of the project of epidemiological surveillance of Community basis for Chagas’ disease by the World Health Organization (WHO), in the departments of Chiquimula, Santa Rosa, Jutiapa, Zacapa and progress in 1998.
Downloads
References
Argueta, J. (1995). Asociación de anormalidades electrocardiográficas con seropositividad para T. cruzi en un área rural endémica de Guatemala. Proyecto de cooperación Guatemala Japón JICA para la Investigación de enfermedades tropicales. p. 73.
Berganza, E. (2010). Situación Epidemiologica de la Enfermedad de Chagas, Área de Salud de Jutiapa.
Chiarpenello, J. (2004). Enfermedad de Chagas (Tripanosomiasis Americana). Evidencia de la actualidad de la práctica ambulatoria; 7:114-119. https://doi.org/10.51987/evidencia.v7i4.5436 DOI: https://doi.org/10.51987/evidencia.v7i4.5436
Monroy, C., Mejía, M., Rodas, A., Tabaru, Y. (1996). Resultados Preliminares de la situación actual de la distribución de vectores de la Enfermedad de Chagas a nivel nacional: Informe Anual No5 (GJET -106) del proyecto de cooperación Guatemala-Japón para la investigación de Enfermedades Tropicales JICA. 137 p.
Monroy, MM. (1986). Mem. VIII Congreso Latinoamericano. Parasitemia. Guatemala. 266p.
Morales, R. (1992). Estudio clínico-serológico de la enfermedad de Chagas en donadores de banco de sangre del hospital nacional de Chiquimula. (tesis de graduación, Facultad de Ciencias Químicas y Farmacia). Universidad de San Carlos de Guatemala. Guatemala.
Nakagawa, J. (2000–2002). Informe de progreso: Proyecto de Control de los Vectores de Chagas. República de Guatemala. Organización Panamericana de la Salud. (1984). Aspecto Clínico de la Enfermedad de Chagas. Boletin Of Sanity Panama. 77,141-155.
Organización Panamericana de la Salud. (1992). Enfermedad de Chagas. Boletin Epidemiológico. Vol. 2.
Orozco, M. (2009). Situación de la Enfermedad de Chagas en Guatemala del año 2008-2009. Informe preliminar. Documento mimeografiado.
Parslow, T., Suites, D., Terr, A., Imboden, J. (2002). Inmunología básica y clínica. (10 a ed.). México: Rebtet GA. Trad.. El manual moderno. p. 917.
Pherson, P., Wahlgren, M. (1982). Intracranial Clasifications probably due to congenital Chagas Disease. American Journal, Tropical Medical. p.31,99-551. https://doi.org/10.4269/ajtmh.1982.31.449 DOI: https://doi.org/10.4269/ajtmh.1982.31.449
Rodríguez, M. (1995). Riesgo de transmisión de la enfermedad de Chagas Laboratorio de Parasitología y Micología del Centro de Investigaciones Regionales. Universidad Autónoma de Yucatán. Centro Estatal de la Transfusión Sanguínea, S.S.A., Mérida, Yucatán, México.
Velásquez, E., Sosa S., Segura E., Ruiz A.M., Porcel B., Yampostis C. (1993). Caracterización Clínica de la Enfermedad de Chagas en Guatemala. Informe Preliminar. Documento Mimeografiado.
Yves, C. (2004). Chagas Disease (American Trypanosomiasis). Medicine. com. Inc. Revista da Sociedade Brasileira de Medicina Tropical. p. 105.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2013 A. Jerez, K. Lange, V. Matta, V. Paredes
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License 4.0 that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.
