Modeling Activity of the Complement System of Ten Native Medicinal Plants of Guatemala

Abstract

The present study evaluated the dit/rc modeling activity of the classical and alternate pathways of the complement system of ethanolic extracts from ten native Guatemalan medicinal plants applying hemolytic assay techniques. The extracts used were flower and root of Dorstenia contrajeren (contrahierba), grated Quercus crispifolia (oak), leaves of Comuna pyramidala (jorokté). Sinuirouba glauca (olive). Pldebodium pseiidoaureun (calahuala). Lippia graveolens (oregano). Nenrolaena tobala (three points). Solatium americanum (blackberry), leaf and root of Peinería alliacea (apacín) and bark of Rhizophora mangle i mangle) which demonstrated anti-protozoan activity in previous studies. The extracts that presented inhibitory activity of the classical pathway of the complement system are root of D. comrajerva (CI 50 = 1 2.50 pg/mL). leaves of P. pseudctatireum, (CQ = 10.50 itg/mL). leaves of S. glauca (CT 50 =5.5() pg/mL). leaves of P. alliacea (IC50 = 5 mg/mL). root of P. alliacea (IC50=14 mg/mL) and leaves of 5. americanum (IC50= 8 mg/mL). Regarding the alternate pathway of the complement, the leaves of P. pseudnaureían presented an activating effect (IC50 =6.17 pg/mL). leaves of P. alliacea (IC50 = 7 mg/mL). root of P. alliacea (LC50 - 6 mg/mL). leaves of 5. americanum (IC50= 14 mg/mL) and leaves of S, glauca (IC50 = 10.00 jUg/mL),