Determination of the half-life of antipyran in the plasma of Guatemalan individuals and its relationship with various factors including nutritional status
DOI:
https://doi.org/10.54495/Rev.Cientifica.v2i2.469Keywords:
determination, half-life, antipyran, plasma, Guatemalan individuals, nutritional statusAbstract
The effect of malnutrition, age, sex, race, region, and body weight on the oxidative system responsible for the metabolism of many drugs, located in the hepatic macrosomes, was studied in a group of Guatemalan individuals. The plasma half-life of antipyrine, a substance metabolized by this system, was used as a parameter for this metabolism. To study the effect of these factors, two groups were used: the first consisting of 30 individuals (21 females and 9 males), ranging in age from 16 to 34 years and with adequate nutritional status; and the second group consisting of 27 individuals (13 females and 14 males), ranging in age from 16 to 35 years and with poor nutritional status. This last group was made up of individuals from various regions of the country. The group of individuals with adequate nutritional status showed lower values for antipyrine half-life, with an average of 12.2 hours (s = 2.38), while the group of malnourished individuals had an average of 20.8 hours (s = 2.38), which is 70.4 times greater than the first group. The difference between the averages was statistically significant (p > 0.05), so it can be concluded that malnutrition increases the half-life of antipyrine in plasma and consequently decreases the capacity of the hepatic microsomal oxidative system, responsible for the metabolism of many drugs, which will probably affect any other drug that is metabolized in a similar way to antipyrine. Age, sex, and body weight did not affect the half-life of antipyrine in either of the two groups studied. Race and region also did not affect this time in the malnourished group. In all cases the differences obtained were not statistically significant (p<0.5s).
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Copyright (c) 1984 Reyna Julieta Roca, Beatriz Batres de Jiménez, José Héctor Aguilar
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