Determination of plasma fibronectin for the early prediction of sepsis in burn patients
DOI:
https://doi.org/10.54495/Rev.Cientifica.v5i1.454Keywords:
determination, plasma fibronectin, early prediction of sepsis, burn patientsAbstract
The present study was conducted on 26 burn patients, divided into three groups: Septic Group (I), Moderately Septic Group (II), and Non-Septic Group (III), as well as a control group. The purpose of this study was to compare fibronectin concentrations during the course of the burn injury with the burned body surface area, the development of sepsis, and the microorganisms present in the wounds.
The study revealed no significant correlation between burned body surface area and fibronectin concentration.
However, a significant difference was found between the fibronectin concentrations of burn patients and the control group.
The septic group had the lowest fibronectin levels compared to the control group mean. The most likely period for developing sepsis was days three through thirteen, a period that coincides with the most severe fibronectin depressions for this group.
An inverse relationship was found between fibronectin concentrations and microbial counts in the wounds of septic patients, which was contrary to that found in the moderately and non-septic patient groups, where fibronectin concentrations remained high compared to the control group mean and microbial counts varied.
The septic patient group had the highest wound microbial count, significantly different from the other groups.
The statistical tests used to determine differences between groups on different days were: multivariate analysis of variance (ANOVA) with an unbalanced complete random model, followed by Turkey's test.
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Copyright (c) 1987 Blanca Elizabeth Samayoa Herrera, Patricia Cáceres Montiel
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