Comparison of two radiopharmaceutical production methods and evaluation of their quality
DOI:
https://doi.org/10.54495/Rev.Cientifica.v5i1.452Keywords:
comparison, radiopharmaceutical production methods, quality evaluationAbstract
This research was conducted to select a production method that offers the greatest advantages in biodistribution and labeling, as well as standardization of a quality control procedure for radiopharmaceuticals to be produced in the Radiopharmacy Laboratory of the University of Nuclear Medicine at the San Juan de Dios General Hospital. To this end, two production methods for five different radiopharmaceuticals were compared, determining their radiochemical purity, biodistribution, and stability. An effective method for determining radiochemical purity was also evaluated, comparing chromatography and electrophoresis methods. A significant difference was observed in their radiochemical purity, biodistribution, and stability, favoring method A (according to the Center for Nuclear Research, Montevideo, Uruguay) for the following radiopharmaceuticals: colloidal sulfur-TC 99m, DTPA-TC 99m (Diethylene triamine pentaacetic acid), calcium glucoheptonate-TC 99m, and sodium pyrophosphate-TC 99m, compared to method B (according to the Chilean Nuclear Energy Commission, Santiago, Chile). This was not the case for the radiopharmaceutical Disida-T c 99m (Diisopropylacetamide-iminodiacetic acid), which favored method B. It was concluded that the chromatography method is more effective than the electrophoresis method for determining radiochemical purity. It was determined that the biodistribution of radiopharmaceuticals in experimental animals is only essential when investigating a new radiopharmaceutical or modifying current formulations, since there is a correlation between the labeling percentages determined by the chromatographic method and those obtained by biodistribution.
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Copyright (c) 1987 María Celestina Portillo Lemus, Sergio Rodolfo Rodríguez Jiménez
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