Ethnopharmacology of plants used by Tz’utujil diabetic patients in Santiago Atitlán, Sololá, Guatemala

Authors

  • Fredy Waldemar López-Valenzuela Escuela de Química Farmacéutica, Facultad de Ciencias Químicas y Farmacia, Universidad de San Carlos de Guatemala
  • Jorge Mario Vargas Ponce Escuela de Biología, Facultad de Ciencias Químicas y Farmacia, Universidad de San Carlos de Guatemala
  • María Nereida Marroquín Tinti Escuela de Química Farmacéutica, Facultad de Ciencias Químicas y Farmacia, Universidad de San Carlos de Guatemala

DOI:

https://doi.org/10.54495/Rev.Cientifica.v31i1.290

Keywords:

traditional medicine, indigenous, DCI, UV, Neurolaena lobata

Abstract

Type 2 diabetes mellitus is a chronic disease with a high prevalence in rural and indigenous communities of Guatemala, in which the use of medicinal plants for its treatment has been reported. In order to know which plants are used by the population for this condition, an ethnopharmacological study was carried out with 36 individuals from the Tz'utujil population of Santiago Atitlán, Sololá, through an anthropological and pharmacological-toxicological analysis of semistructured interviews and open questionnaires. Nineteen plants were identified, and the disease consensus index (DCI) and the value in use (UV) were calculated to assess the knowledge and relative importance of each species; both values ​​help to understand the cultural relevance, that is, the importance of medicinal species for the population. The five plants with the higher cultural relevance were Neurolaena lobata R.Br. ex Cass. (DCI = 0.4074, UV = 0.0084), Artemisia absinthium L. (DCI = 0.1481, UV = 0.0027), Psidium guajava L. (DCI = 0.1111, UV = 0.0023), Tanacetum parthenium (L.) Sch.Bip. (DCI = 0.0741, UV = 0.0015) and Coffea arabica L. (DCI = 0.0741, UV = 0.0015). It was determined that N. lobata and P. guajava have a high potential to treat diabetes, C. arabica and T. parthenium can cause adverse effects and interactions with certain medications, and A. absinthium can be dangerous if consumed. However, further studies of the isolated secondary metabolites responsible for antidiabetic activity are required to establish safe doses, adverse effects, interactions and toxicology.

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References

Al-Haj, N., Aburjai, T. A., Taha, M. O., & Disi, A. M. (2011). Thujone corrects cholesterol and triglyceride profiles in diabetic rat model. Natural Product Research, 25(12), 1180–1184. https://doi.org/10.1080/14786419.2010.496116 DOI: https://doi.org/10.1080/14786419.2010.496116

Al-Malki, A. L. (2019). Shikimic acid from Artemisia absinthium inhibits protein glycation in diabetic rats. International Journal of Biological Macromolecules, 122, 1212–1216. https://doi.org/10.1016/j.ijbiomac.2018.09.072 DOI: https://doi.org/10.1016/j.ijbiomac.2018.09.072

Al-Qazaz, H. K., Sulaiman, S. A., Hassali, M. A., Shafie, A. A., Sundram, S., Al-Nuri, R., & Saleem, F. (2011). Diabetes knowledge, medication adherence and glycemic control among patients with type 2 diabetes. International Journal of Clinical Pharmacy, 33(6), 1028–1035. https://doi.org/10.1007/s11096-011-9582-2 DOI: https://doi.org/10.1007/s11096-011-9582-2

American Diabetes Association. (2019). Standars of Medical Care in Diabetes. Diabetes Care, 42(1), S1–S2 https://doi.org/10.2337/dc19-Sint01 DOI: https://doi.org/10.2337/dc19-Sint01

Andrade-Cetto, A., Becerra-Jiménez, J., Martínez-Zurita, E., Ortega-Larrocea, P., & Heinrich, M. (2006). Disease-Consensus Index as a tool of selecting potential hypoglycemic plants in Chikindzonot, Yucatán, México. Journal of Ethnopharmacology, 107(2), 199–204. https://doi.org/10.1016/j.jep.2006.03.005 DOI: https://doi.org/10.1016/j.jep.2006.03.005

Andrade-Cetto, A., Cruz, E. C., Cabello-Hernández, C. A., & Cárdenas-Vázquez, R. (2019). Hypoglycemic Activity of Medicinal Plants Used among the Cakchiquels in Guatemala for the Treatment of Type 2 Diabetes. Evidence-Based Complementary and Alternative Medicine, 2019. https://doi.org/10.1155/2019/2168603 DOI: https://doi.org/10.1155/2019/2168603

Andrade-Cetto, A., & Heinrich, M. (2011). From the field into the lab: Useful approaches to selecting species based on local knowledge. Frontiers in Pharmacology, 2, 1–5. https://doi.org/10.3389/fphar.2011.00020 DOI: https://doi.org/10.3389/fphar.2011.00020

Andrews, C. M., Wyne, K., & Svenson, J. E. (2018). The Use of Traditional and Complementary Medicine for Diabetes in Rural Guatemala. Journal of Health Care for the Poor and Underserved, 29(4), 1240–1258. https://doi.org/10.1353/hpu.2018.0092 DOI: https://doi.org/10.1353/hpu.2018.0092

Barreno, F. (2010, marzo). Recuperación y revalorización del conocimiento etnomedicinal en once municipios de la reserva de usos múltiples cuenca del lago de Atitlán.http://glifos.senacyt.gob.gt/digital/fodecyt/fodecyt%202008.27.pdf

Bernard, R. (2011). Research Methods in Anthropology (5a ed.). AltaMira Press.

Bream, K. D. W., Breyre, A., Garcia, K., Calgua, E., Chuc, J. M., & Taylor, L. (2018). Diabetes prevalence in rural Indigenous Guatemala: A geographic-randomized cross-sectional analysis of risk. PLoS ONE, 13(8). https://doi.org/10.1371/journal.pone.0200434 DOI: https://doi.org/10.1371/journal.pone.0200434

Brenner, G. M., & Stevens, C. W. (2018). Farmacología Básica (5a ed.). Elsevier Inc.

Cáceres, A., & Cruz, S. (2019). Detection and Validation of Native Plants Traditionally Used as Medicine in Guatemala. Current Traditional Medicine, 5(1), 5–30. https://doi.org/10.2174/2215083805666190327172409 DOI: https://doi.org/10.2174/2215083805666190327172409

Chary, A., Greiner, M., Bowers, C., & Rohloff, P. (2012). Determining adult type 2 diabetes-related health care needs in an indigenous population from rural Guatemala: A mixed-methods preliminary study. BMC Health Services Research, 12(1). https://doi.org/10.1186/1472-6963-12-476 DOI: https://doi.org/10.1186/1472-6963-12-476

Chen, D., Rivera-Andrade, Á., González, J., Burt, D., Mendoza-Montano, C., Patrie, J., Luna, M., & Prevalence, L. M. (2017). Prevalence of risk factors for noncommunicable diseases in an indigenous community in Santiago Atitlán, Guatemala. En Pan American Journal of Public Health. 41:e7. https://iris.paho.org/handle/10665.2/33837 DOI: https://doi.org/10.26633/RPSP.2017.7

Cheng, F. C., Shen, S. C., & Wu, J. S. B. (2009). Effect of guava (Psidium guajava L.) leaf extract on glucose uptake in rat hepatocytes. Journal of Food Science, 74(5), 132–138. https://doi.org/10.1111/j.1750-3841.2009.01149.x DOI: https://doi.org/10.1111/j.1750-3841.2009.01149.x

Cruz, E., & Andrade-Cetto, A. (2015). Ethnopharmacological field study of the plants used to treat type 2 diabetes among the Cakchiquels in Guatemala. Journal of Ethnopharmacology, 159, 238–244. https://doi.org/10.1016/j.jep.2014.11.021 DOI: https://doi.org/10.1016/j.jep.2014.11.021

Daradka, H. M., Abas, M. M., Mohammad, M. A. M., & Jaffar, M. M. (2014). Antidiabetic effect of Artemisia absinthium extracts on alloxan-induced diabetic rats. Comparative Clinical Pathology, 23(6), 1733–1742. https://doi.org/10.1007/s00580-014-1963-1 DOI: https://doi.org/10.1007/s00580-014-1963-1

de Albuquerque, U. P., de Medeiros, P. M., de Almeida, A. L. S., Monteiro, J. M., de Freitas Lins Neto, E. M., de Melo, J. G., & dos Santos, J. P. (2007). Medicinal plants of the caatinga (semi-arid) vegetation of NE Brazil: A quantitative approach. Journal of Ethnopharmacology, 114(3), 325–354. https://doi.org/10.1016/j.jep.2007.08.017 DOI: https://doi.org/10.1016/j.jep.2007.08.017

Etkin, N. L. (1988). Cultural Constructions of Efficacy. En S. van Der & S. Reynolds (Eds.), The context of medicines in developing countries. Kluwer Academic Publishers. https://doi.org/10.1007/978-94-009-2713-1 DOI: https://doi.org/10.1007/978-94-009-2713-1_16

Evans, J., Goldfine, I., Maddux, B., & Grodsky, G. (2003). Are Oxidative Stress -Activated Signaling Pathways Mediators of Insulin Resistance and B-Cell Dysfunction? Diabetes, 52, 1–8. https://doi.org/10.2337/diabetes.52.1.1 DOI: https://doi.org/10.2337/diabetes.52.1.1

Heinrich, M., Edwards, S., Moerman, D. E., & Leonti, M. (2009). Ethnopharmacological field studies: A critical assessment of their conceptual basis and methods. Journal of Ethnopharmacology, 124(1), 1–17. https://doi.org/10.1016/j.jep.2009.03.043 DOI: https://doi.org/10.1016/j.jep.2009.03.043

Heinrich, M., & Jäger, A. (2015). Ethnopharmacology. John Wiley & Sons, Ltd. DOI: https://doi.org/10.1002/9781118930717

Heinrich, M., & Verpoorte, R. (2014). Good practice in ethnopharmacology and other sciences relying on taxonomic nomenclature. Journal of Ethnopharmacology, 152(3), 285–286. https://doi.org/10.1016/j.jep.2014.01.016 DOI: https://doi.org/10.1016/j.jep.2014.01.016

Hughes, J. (2004). Gender, Equity, and Indigenous Women’s Health in the Americas (The Gender and Health Unit). Pan-American Health Organization.

International Diabetes Federation. (2021). IDF Diabetes Atlas (10a ed.). https://www.diabetesatlas.org

Jankowska-Polańska, B., Uchmanowicz, I., Dudek, K., & Mazur, G. (2016). Relationship between patients’ knowledge and medication adherence among patients with hypertension. Patient Preference and Adherence, 10, 2437–2447. https://doi.org/10.2147/PPA.S117269 DOI: https://doi.org/10.2147/PPA.S117269

Khan, H. B., Rajendran, D., Bai, M. R., & Sorimuthu, S. (2013). Protective effect of Psidium guajava leaf extract on altered carbohydrate metabolism in streptozotocin-induced diabetic rats. Journal of Dietary Supplements, 10(4), 335–344. https://doi.org/10.3109/19390211.2013.830677 DOI: https://doi.org/10.3109/19390211.2013.830677

Koh, K. B. (2018). Estrés y síntomas somáticos: perspectivas biopsicosocioespirituales. Springer Nature Suiza AG. https://doi.org/10.1007/978-3-030-02783-4 DOI: https://doi.org/10.1007/978-3-030-02783-4

Kuang, A., Erlund, I., Herder, C., Westerhuis, J. A., Tuomilehto, J., & Cornelis, M. C. (2018). Lipidomic response to coffee consumption. Nutrients, 10(12), 1–12. https://doi.org/10.3390/nu10121851 DOI: https://doi.org/10.3390/nu10121851

Lachenmeier, D. W., & Walch, S. G. (2011). The choice of thujone as drug for diabetes. Natural Product Research, 25(20), 1890–1892. https://doi.org/10.1080/14786419.2011.622279 DOI: https://doi.org/10.1080/14786419.2011.622279

Michel, J., Mahady, G. B., Soejarto, D. D., Kelley, M., Duarte, R. E., Huang, Y., Orjala, J., Veliz, M., & Cáceres, A. (2012). Q’eqchi ethnobotany and ethnopharmacology: Results of an investigation on women’s health and implications for youth engagement towards the conservation of traditional medicine. Acta Horticulturae, 964, 235–250. DOI: https://doi.org/10.17660/ActaHortic.2012.964.29

Mousa, S. A. (2016). Antithrombotic Effects of Naturally Derived Products on Coagulation and Platelet Function. En Anticoagulants, Antiplatelets and Thrombolytics (2a ed., Vol. 663, pp. 229–240). Humana Press. https://doi.org/10.1007/978-1-60761-803-4-9 DOI: https://doi.org/10.1007/978-1-60761-803-4_9

Municipalidad de Santiago Atitlán, Ministerio de Ambiente y Recursos Naturales, & Programa de las Naciones Unidas para el Desarrollo. (2021). Plan de desarrollo del Municipio de Santiago Atitlán con Enfoque Territorial, Género y Pertinencia Cultural 2012-2023. Secretaria de planificación y programación.

Nieblas-Bedolla, E., Bream, K. D., Rollins, A., & Barg, F. K. (2019). Ongoing challenges in access to diabetes care among the indigenous population: perspectives of individuals living in rural Guatemala. International Journal for Equity in Health, 18(1). https://doi.org/10.1186/s12939-019-1086-z DOI: https://doi.org/10.1186/s12939-019-1086-z

Punnett, B., Ford, D., Galperin, B. L., & Lituchy, T. (2017). The emic-etic-emic research cycle. Academy of International Business, 17(1), 3–6. https://doi.org/10.46697/001c.16865 DOI: https://doi.org/10.46697/001c.16865

Ramírez, G., Zavala, M., Pérez, J., & Zamilpa, A. (2012). In vitro screening of medicinal plants used in Mexico as antidiabetics with glucosidase and lipase inhibitory activities. Evidence-Based Complementary and Alternative Medicine, 2012. https://doi.org/10.1155/2012/701261 DOI: https://doi.org/10.1155/2012/701261

Reyes, F., Pérez, M., Figueredo, E., Ramírez, M., & Jiménez, Y. (2016). Tratamiento actual de la diabetes mellitus tipo 2. Correo Científico Médico de Holguín, 20(1), 289–292.

Rodriguez, R. (2008). Estudio de las plantas medicinales conocidas por la población de la comunidad Primavera, del municipio de Ixcán, Quiché, utilizando técnicas etnobotánicas. [Tesis de Licenciatura]. Facultad de Agronomía, Universidad de San Carlos de Guatemala.

Shokouh, P., Jeppesen, P. B., Hermansen, K., Nørskov, N. P., Laustsen, C., Hamilton-Dutoit, S. J., Qi, H., Stødkilde-Jørgensen, H., & Gregersen, S. (2018). A combination of coffee compounds shows insulin-sensitizing and hepatoprotective effects in a rat model of diet-induced metabolic syndrome. Nutrients, 10(1), 6. https://doi.org/10.3390/nu10010006 DOI: https://doi.org/10.3390/nu10010006

Tabakián, G. (2017). Etnomedicina y Etnobotánica en el departamento de Tacuarembó, Uruguay. Revista Uruguaya de Antropología y Etnografía, 2(2), 61–72. https://doi.org/https://doi.org/10.29112/2.2.4 DOI: https://doi.org/10.29112/2.2.4

Tobyn, G., & Whitelegg, M. (2011). The Western Herbal Tradition. En Textbook of Natural Medicine (pp. 591–594). Churchill Livingstone. https://doi.org/10.10.1016/B978-0-443-10344-5.00016-1

Umathe, S. N., Dixit, P. V., Kumar, V., Bansod, K. U., & Wanjari, M. M. (2008). Quercetin pretreatment increases the bioavailability of pioglitazone in rats: Involvement of CYP3A inhibition. Biochemical Pharmacology, 75(8), 1670–1676. https://doi.org/10.1016/j.bcp.2008.01.010 DOI: https://doi.org/10.1016/j.bcp.2008.01.010

United Nations. (2013). State of the world’s indigenous peoples. https://www.un.org/development/desa/indigenouspeoples/publications/state-of-the-worlds-indigenous-peoples.html

van Oudenhoven, J. P. (2017). Emic and Etic Research. The International Encyclopedia of Intercultural Communication, 1–7. https://doi.org/10.1002/9781118783665.ieicc0103 DOI: https://doi.org/10.1002/9781118783665.ieicc0103

Vargas, J. (2018). Etnofarmacología de las principales plantas medicinales utilizadas por los q’eqchi’es en tres comunidades de Alta Verapaz, Guatemala. Frontiers in Pharmacology, 9(1246), 1-14. https://doi.org/10.3389/fphar.2018.01246 DOI: https://doi.org/10.3389/fphar.2018.01246

Woodward, S. C., Bereznicki, B. J., Westbury, J. L., & Bereznicki, L. R. E. (2016). The effect of knowledge and expectations on adherence to and persistence with antidepressants. Patient Preference and Adherence, 10, 761–768. https://doi.org/10.2147/PPA.S99803 DOI: https://doi.org/10.2147/PPA.S99803

Published

2022-12-31

How to Cite

López-Valenzuela, F. W. ., Vargas Ponce, J. M. ., & Marroquín Tinti, M. N. . (2022). Ethnopharmacology of plants used by Tz’utujil diabetic patients in Santiago Atitlán, Sololá, Guatemala. Revista Científica, 31(1), 3–14. https://doi.org/10.54495/Rev.Cientifica.v31i1.290

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