Use of a gastrointestinal absorption simulator with artificial membranes in determining the bioavailability of tablets

Comparison and evaluation of in vitro and in vivo results

Authors

  • Arturo Letona Martínez Faculty of Chemical Sciences and Pharmacy
  • Rafael Letona Romero Faculty of Chemical Sciences and Pharmacy

DOI:

https://doi.org/10.54495/Rev.Cientifica.v1i1.480

Keywords:

gastrointestinal absorption simulator, artificial membranes, bioavailability of tablets, comparison, evaluation, in vitro results, in vivo results

Abstract

This research contains a comparative evaluation of methods and results obtained from in vitro assays using a Gastrointestinal Absorption Simulator (SAGI*) and in vivo assays in humans to determine the bioavailability of a drug. Bioavailability is defined as the speed and ease with which a large amount of a drug administered in a certain pharmaceutical form reaches the site where its action is needed, and the frequency with which this occurs. Diffusion and absorption constants were determined, in addition to establishing plasma concentration curve values ​​for the drug in question. These are, together, of utmost importance for determining some of the factors that modify bioavailability, depending on the method used to determine it. It was successfully concluded that using a SAGI, it is possible to determine the bioavailability of a drug accurately and reproducibly, just as we would in a human organism, presenting minimal variations in terms of gastrointestinal absorption, which are significantly reduced once adjusted to gastric pH, motility and gastrointestinal enzyme activity. The use of SAGI presents an alternative for the quality control of medications consumed by the Guatemalan population, since it is a more cost-effective method than the in vivo assay panel and, at the same time, complements the physical and chemical quality control tests that have been traditionally performed.

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References

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Published

1983-12-31

How to Cite

Letona Martínez, A., & Letona Romero, R. (1983). Use of a gastrointestinal absorption simulator with artificial membranes in determining the bioavailability of tablets: Comparison and evaluation of in vitro and in vivo results. Revista Científica, 1(1), 19–26. https://doi.org/10.54495/Rev.Cientifica.v1i1.480

Issue

Section

Original Research Papers

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