Effect of protein-calorie malnutrition on serum glutathione S-transferase activity
DOI:
https://doi.org/10.54495/Rev.Cientifica.v5i1.453Keywords:
effect, protein-calorie malnutrition, serum glutathione S-transferase activityAbstract
Serum glutathione S-transferase activity was determined in 49 children with protein-calorie malnutrition. Nutritional status was assessed using anthropometric indicators: weight-for-age, height-for-age, and weight-for-height. Glutathione S-transferase levels were determined by measuring serum enzyme activity using reduced glutathione and 1-chloro-2,4-dinitrobenzene as substrates. Glutamic pyruvic transaminase levels were determined as an index of liver cell integrity.
In none of the 3 indicators did the sample cover the 4 established nutritional status classification categories. However, glutathione S-transferase values in the most deficient categories showed a decrease of between 15 and 19% compared to the concentrations in the least deficient categories. The differences in the indicators weight-for-age (p<0.05) and weight-for-height (p<0.005) were statistically significant. Serum glutamic pyruvic transaminase levels in the most deficient categories were 19 to 60% higher than those in the least deficient categories.
It was concluded that protein-calorie malnutrition decreases serum glutathione S-transferase levels. This decrease, despite the possible increase in enzyme release from the hepatic cytosol, suggests that hepatic glutathione S-transferase concentrations are significantly reduced in this nutritional deficiency.
The reduction in these Phase II detoxification enzymes is consistent with previous studies that have shown that drug metabolism is altered during protein-calorie malnutrition.
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Copyright (c) 1987 Rubén D. Velásquez Miranda, José Héctor Aguilar
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