In vitro pharmacological and toxicological evaluation of some plants commonly used in Guatemala against malaria
DOI:
https://doi.org/10.54495/Rev.Cientifica.v9i1.393Keywords:
pharmacological evaluation, toxicological evaluation, "in vitro", malaria, plants, GuatemalaAbstract
Malaria, an acute and frequently chronic disease caused by parasites of the genus Plasmodium, is still the most important parasitic disease worldwide. It is found in approximately one hundred countries, of which around one million children die annually from this disease in Africa alone. The reasons why malaria still represents a serious problem are several: the acquired resistance of mosquitoes to insecticides and the difficulty in implementing or maintaining effective control schemes.
The resistance of the main causative agents, Plasmodium falciparum and Plasmodium vivax, to the classic drugs chloroquine and primaquine, has probably been the most important problem. Population migration has also contributed to the spread of this resistance to other regions.
This is how a great interest has arisen worldwide in searching for new antimalarial agents with a mechanism of action different from those of the drugs already available, and because of this, research on plants has become even more important today, especially after the discovery of the new antimalarial agent artemisinin, an active ingredient isolated from the plant Artemissia annua, from China.
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Copyright (c) 1993 Medinilla Aldana Beatriz Eugenia
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