Determination of the incidence and frequency of blood group antigens in blood donors
DOI:
https://doi.org/10.54495/Rev.Cientifica.v7i1.438Keywords:
determination, incidence, frequency, blood group antigens, blood donorsAbstract
The aim of this study was to establish the incidence and frequency of erythrocyte antigens in a representative population of blood donors. For this purpose, 445 donors from the Blood Bank of the General Hospital were typed for the antigens of seven blood systems: ABO, Rhesus, MNSs, Kell, Lewis, Duffy and P.
Blood groups O, A, B and AB were found in 68.8, 19.6, 9.4 and 2.2% respectively. The A subgroup was present in 80.4% of donors positive for the A antigen.
The MNSs, M, N, S and s system antigens were present in 89.9%, 75.5%, 42.7% and 50.1% respectively, with the most frequent phenotypes being M+N+ (65.5%), M+N- (23.8%), S-s+ (31.9%) and S-s- (25%).
The Kell antigen, the lowest in frequency in the study, was present in 3.1% of the donors, while the Cellano antigen, the second most frequent after the D antigen, was found in 97.3% of the donors, with the most frequently found phenotype being k-k+ in 93.7% of the population.
The most frequent phenotype of the Lewis system, Le(a-b+), was present in 66.4% of the donors, with the Leb antigen having a higher frequency than the Lea antigen.
The Fya and P1 antigens of the Duffy and P systems were found in 77.2 and 68.7% respectively.
Knowing the distribution of these antigens in the population, a panel of erythrocytes with known antigens was created with the blood of the donors studied, which was preserved at -20°C by freezing techniques, and can be used in the detection of irregular antibodies in cases of blood incompatibility in polytransfused and multiparous women, as well as in haemolytic disease of the newborn.
Downloads
References
Gamma Biologicals Blood grouping serums, anti-A, anti-B, anti-AB, USA; Houston, Texas: Gamma Laboratories, 1986, 2p.
Immucor. Anti-A1 lectin (Dolichos biflorus) blood grouping lectin. USA; Georgia: Immucor Inc. 1983 2p.
Immucor. Blood grouping serum (Mouse monoclonal) anti-Lea & anti-Leb. USA; Georgia: Immucor Inc. 1983. 2p.
Immucor. Blood grouping serum anti-M. USA; Georgia: Immucor Inc 1983. 2p.
Immucor. Anti-N lectin (Vicia gramínea). USA; Georgia: Immucor Inc. 193. 2p.
Immucor. Blood grouping serum anti-P1 for saline tube test. USA; Georgia: Immucor Inc. 1984. 2p.
Immucor. Blood grouping anti-K, anti-k, for indirect antiglobuline test. USA; Georgia: Immucor Inc. 1983. 2p.
Immucor. Blood grouping serum anti-Fya for indirect antiglobuline test. USA; Georgia: Immucor Inc. 1985. 2 p.
Gamma Biologicals. Blood grouping serums, anti -C, anti -E, anti -c. anti-e, USA; Houston, Texas: Gamma Laboratories, 1986. 2p.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 1989 María de los Angeles Prado B, Gloria Hidalgo
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License 4.0 that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.
