Dosage of phenobarbital and diphenylhydantoin in patients referred to the toxicological information and assistance center of the Faculty of Chemical Sciences and Pharmacy

Authors

  • A.L. Quiñonez de Padilla University of San Carlos of Guatemala
  • M.A. Pardo de Chavez University of San Carlos of Guatemala

DOI:

https://doi.org/10.54495/Rev.Cientifica.v8i1.403

Keywords:

phenobarbital, diphenylhydantoin, patients referred to the toxicological information and assistance center, Faculty of Chemical Sciences and Pharmacy

Abstract

This study covers the analysis of the results of the dosages carried out during 1987 and 1988 of phenobarbital and diphenylhydantoin through the Toxicological Information and Assistance Center -CIAT-, of the Faculty of Chemical Sciences and Pharmacy, finding that of the 508 lysis performed only 18.2% of the patients for phenobarbital and 46% for diphenylhydantoin, presented concentrations corresponding to the normal range.

With these data it was confirmed that the controls of the blood levels are necessary to achieve an adequate dose for each patient and with this individualization achieve the desired therapeutic benefits.

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References

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Ellenhorn M , Barceloux D . Medical Toxicology. New York: Elsevier. 1988. 1512 p.

Kaye S. Handbook of Emergency Toxicology. 3a. ed. Illinois: Charles Thomas. 1977, 514 p.

Litter M. Farmacología. 6a. ed. Argentina: El Ateneo. 1953.

Olesen VO. Determinación de Fenobarbital y Difenilhidantoína en suero por Espectrofotomctría Ultravioleta. Scand. J. Clin. Lab. Invest. 20,63-69, 1967. DOI: https://doi.org/10.1080/00365516709076922

Sunshine I. Methodology for Analytical Toxicology. Florida: CRC Press. 1978,478 p.

Published

1991-12-31

How to Cite

Quiñonez de Padilla, A., & Pardo de Chavez, M. (1991). Dosage of phenobarbital and diphenylhydantoin in patients referred to the toxicological information and assistance center of the Faculty of Chemical Sciences and Pharmacy. Revista Científica, 8(1), 5–8. https://doi.org/10.54495/Rev.Cientifica.v8i1.403

Issue

Section

Original Research Papers

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