Determination of enantiometric purity by polarimetry
DOI:
https://doi.org/10.54495/Rev.Cientifica.v3i1.466Keywords:
determination, enantiometric purity, polarimetryAbstract
To help overcome the difficulties faced by developing countries in chemical research involving advanced instrumental technology, and with the aim of developing a simple method for determining enantiomeric purity, a mathematical model was deduced based on geometric considerations related to the specific optical rotation angles exhibited by optically active compounds and their enantiomeric mixtures, which gave rise to a mathematical equation that makes the aforementioned analytical determination possible. The statistical analysis of the results demonstrated that both the proposed mathematical model and the polarimetric method are precise, accurate, statistically valid, and significant, and their application provides results identical and equivalent to those obtained by Nuclear Magnetic Resonance methodology. This leads to the establishment of a new, available, and less expensive methodology that contributes not only to developing the analytical infrastructure of chemistry but also to expanding the research horizons of other scientific disciplines.
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Copyright (c) 1985 Sergio Enrique Mejía, Pedro Liska Kucera
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