Effect of linoleic acid, glutathione, and zinc administration on alcohol intake and its relationship with gamma-glutamyl transpeptidase
DOI:
https://doi.org/10.54495/Rev.Cientifica.v1i1.481Keywords:
effect, linoleic acid administration, glutathione administration, zinc administration, alcohol intake, alcohol intake's relationship with gamma-glutamyl transpeptidase, gamma-glutamyl transpeptidaseAbstract
High doses of ethanol have been observed to cause liver damage, leading to increased activity of the gamma-glutamyl transpeptidase enzyme in plasma. When a group of rats were subjected to alcohol and their plasma activity was determined, it was found to be elevated, compared to three groups of rats treated with alcohol and glutathione, zinc, and linoleic acid, respectively, in whom this activity was decreased. This suggests a hepatoprotective action of glutathione, zinc, and linoleic acid against the harmful effects of ethanol.
Downloads
References
Lieber CS. Alcohol, protein metabolism, and liever injury. Gastroeq 1980; 79:33-379. https://doi.org/10.1016/0016-5085(80)90157-2
Lieber CS, Schmid R. Theeffectof ethanol on fatty acid metabolism stimulation of hepatic fatty acid synthesis in vitro. J Clin Invest 1961; 40:394-399. https://doi.org/10.1172/JCI104266
Leevy S, Baker M. Vitamins and alcoholism. Amer J Clin Nutr 1968; 21:1325-1328. https://doi.org/10.1093/ajcn/21.11.1325
Víctor M, Adams R. Symposium on neurological and hepatic complications of alcoholism. Amer J Clin Nutr 1960; 9(4): 379-397.
Pokroosky A. Some biochemical aspects of chronic alcohol intoxication. Nutr Metab 1977; 21:194-196. https://doi.org/10.1159/000175764
Feuerlein W. Neuropsychiatric disorders of alcoholism. Nutr Metab 1977; 21:163-174. https://doi.org/10.1159/000175761
Bagrel A, d'Hotaud A, Gueguen R, Siest G, Relation between reported alcohol consumption and certain biological variable in an "unselected population. Clin Chem 1979;2517:1242-1246. https://doi.org/10.1093/clinchem/25.7.1242
Horner F, "et al". Dynamic changes of serum gamma-glutamyI transferase in chronic alcoholism. Enzyme 1975;24:217:223. https://doi.org/10.1159/000458662
Wilkinson JH. The principies and practice of diagnostic enzymology. Boston. Edward Arnol Publication. 1976. 592.p.
Schiele F, Guilmin AM, Dietienne H, Siest G. Gamma-glutamyl transferase activity in plasma: stadistical distribution, individual variations and reference intervals. Clin Chem 1977;23(6) .-1023-1028. https://doi.org/10.1093/clinchem/23.6.1023
VonWartbur JP. Metabolic consecuences of alcohol consumption. Nutr Metab 1977;21:153-162. https://doi.org/10.1159/000175760
Lieber CS, Schmid R. Stimulation of hepatic fatty acid synthesis by ethanol. Amer J Clin Nutr 1961;9:436-438. https://doi.org/10.1093/ajcn/9.4.436
Weil DG. The pathophysiology of alcohol and acetaldehyde metabolism in the liver. Eur J Clin Invest 1978;8:163-165. https://doi.org/10.1111/j.1365-2362.1978.tb00838.x
Smith ME, Newman HW, The rate of ethanol metabolism in fed and fasting animáis. J Biol Chem 1959;234(6): 1544-1549. https://doi.org/10.1016/S0021-9258(18)70047-1
Thaler H. Alcohol consumption and diseases of the liver. Nutr Metab 1977;21:186-193. https://doi.org/10.1159/000175763
Giroux El. Durieux M. Schechter PJ. A study of zinc distribution in human serum. Bioinorg Chem 1976;5:21. https://doi.org/10.1016/S0006-3061(00)82019-0
Sullivan FJ, Lankford HG. Urinary excretion of zinc in alcoholism and postalcoholic cirrhosis. Amer J Clin Nutr 1962;10:153-157. https://doi.org/10.1093/ajcn/10.2.153
Valle BL, Wacker CEW, Bartholomay FA, Robin DE. Zinc metabolism in hepatic disfunction. N Engl J Med 1956;255(9) .-403-408. https://doi.org/10.1056/NEJM195608302550901
Russel RM. Vitamin A and zinc metabolism in alcoholism. Amer J Clin Nutr 1980;33:2741-2749. https://doi.org/10.1093/ajcn/33.12.2741
Lieber J. Prostaglandin E-jin affective disorders and alcoholism. Brit Med J 1980,453(6237) :37. https://doi.org/10.1136/bmj.281.6237.453-a
Horrolien DF, Mankun MS. Possible role the prostaglandins E-j in the affective disorders and in alcoholism. Brit Med J 1980;7:1363-1366. https://doi.org/10.1136/bmj.280.6228.1363
Viña EM, Guerri C, Romero F. Effect of ethanol on glutatione concentration in isolated hepatocytes. Biochem J 1980;188:549-552. https://doi.org/10.1042/bj1880549
Lieber CS. Metabolism of alcohol. Sci Amer 1976.234(3): 25-34. https://doi.org/10.1038/scientificamerican0376-25
Lieber CS, DeCarli LM. Animal models of ethanol dependence and liver injury in rats and baboons. Fed Proc 1976;35:1232-1236.
Szasz G, "et al". Zeitschrift Klinic Für Chemic U Klin Niochem 1974; 12:228.
Persin JO, Van der Slik W. J Clin Chem Biochem 1976;14:421. https://doi.org/10.1515/cclm.1976.14.1-12.421
Levin J. Fundamentos de estadística en la investigación social. Del valle, haría V trad. 1978. 305p.
Lewis EA. Bioestadística. México. Compañía editorial continental, S.A. 1979. 2979p-
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 1983 Silvia Sandra Regina García Alfaro, Clemencia Gálvez de Avila
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License 4.0 that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.
