Contribution to the pharmacological study of a group of medicinal plants used as diuretics
DOI:
https://doi.org/10.54495/Rev.Cientifica.v3i1.464Keywords:
contribution , pharmacological study, medicinal plants, diureticsAbstract
The diuretic, uricosuric, and saluretic activity of the alcoholic extract of Acalypha guatemalensis (cancer herb), Achillea millefolium (milkwort), Buddleia americana (sage), Cissampelos pareirae (honeycomb), Foeniculum vulgare (fennel), Fragaria vesca (strawberry), Guaiacum guatemalensis (guaiac), Hybiscus sabdariffa (rosehip), Plantago major (plantain), Polypodium ca lagúala (calaguala), Sambucas mexicana (elderberry), Tecoma stans (timboque), Urtica dioica (nettle), and Zea mays (corn) was studied in albino rats, with oral administration of the alcoholic extract at a dose of 500 mg/kg.
The diuretic and saluretic activity of these extracts was compared with that of hydrochlorothiazide, the reference drug. The extracts that exhibited a diuretic effect were roselle, rosehip, and timboque. The latter two reached their maximum effect after two hours, while rosehip maintained its effect throughout the entire experiment (six hours). Sodium excretion was increased by all three species, and potassium excretion was only increased by rosehip.
The mean uric acid excretion was increased by elderberry, fennel, and rosehip, but none of the species exceeded the increase caused by Probenedda, used as the reference drug for uric acid excretion.
The mean serum uric acid concentration, determined in blood samples taken at the end of the experiment, showed a decrease compared to the value determined as normal, but this difference was not statistically significant.
The experiment suggests that they have a lesser diuretic effect than hydrochlorothiazide, rosehip, and timboque. Rosehip showed greater diuretic and saluretic activity than this drug, offering the advantage of lower potassium excretion than hydrochlorothiazide, while increasing uric acid excretion.
Elderberry and fennel were also observed to exhibit uricosuric activity. Importantly, these two species increase uric acid excretion without increasing urine volume.
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Naik VR, Agshikar NV, Abraham GJ. Cucumis trigonus Roxb. II diuretic activity. J. Ethnopharmacology, 1981.3: 17-19. https://doi.org/10.1016/0378-8741(81)90011-8 DOI: https://doi.org/10.1016/0378-8741(81)90011-8
Richard J, Henry MD. Clinical Chemistry; principies and technics. Barcelona: JIMS, 1969.
Fong Harry HS, Tinwa M, Fanrsworlh NR. Phytochemical Screning. University of Illinois: Department of Pharmacognosy and pharmacology; College of Pharmacy, Santa Cruz LH, trad. Guatemala: Facultad de Ciencias Químicas y Farmacia.
Guytón A. Tratado de Fisiología Médica. 5 ed. Folch A., Espinoza R., trad. México: Interamericana, 1977. 1159p.
Gambhir MS, Goyal SK, Gupta HC. A compara ti ve evaluation of the diuretic efficacy of mercuramide, hidrochortiazide, ethacrynic acid and furosemide. Ind J Med Sciences, 1979;2: 262-65.
Whight MB, et al. Diuretic, Cardiac failure and potasium depletion: a rational approach. Med. J. Aust., 1974.2: 831-33. https://doi.org/10.5694/j.1326-5377.1974.tb93704.x DOI: https://doi.org/10.5694/j.1326-5377.1974.tb93704.x
Friedman A, Steele H. Supersaturation of uriñe with uric acid and urate: response a uricosuric diuretic. J Lab Clin Med 1978; 92(3): 447-54.
Pearson RM, Havard CWH, Bulpitt CJ. Biochemical and Haematológical changes induced by tienilic acid combined with propanolol in essential hypertension. The Lancet, 1979; 3: 697-99. https://doi.org/10.1016/S0140-6736(79)91149-8 DOI: https://doi.org/10.1016/S0140-6736(79)91149-8
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Copyright (c) 1985 Ana María Martínez Clavería, Beatriz B. de Jiménez
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